Hernia extraforaminal en el espacio L5-S1 tratada por abordaje transfacetario endoscópico. Presentación de un caso y nota técnica / Extraforaminal L5-S1 disc herniation treated by endoscopic transfacet approach. Case report and technical note

Las hernias de disco extraforaminales en el espacio L5-S1 suelen ser difíciles de tratar por su complicado acceso y el riesgo de lesión nerviosa. Se presenta el caso de un paciente con discopatía en L5-S1 izquierda que fue tratado mediante discectomía endoscópica por abordaje símil Wiltse transfacetario. Este tipo de abordaje permite el acceso seguro a las hernias extraforaminales en el espacio L5-S1 evitando la manipulación e irritación de la raíz de L5. Nivel de Evidencia: IV

Extraforaminal L5-S1 disc herniations are usually difficult to treat due to their complicated access and risk of nerve injury. We present the case of a patient with left L5-S1 disc disease who was treated by endoscopic discectomy using a transfacet Wiltse-like approach. This method provides safe access to L5-S1 extraforaminal herniations while avoiding manipulation and irritation of the L5 root. Level of Evidence: IV

Flap of the sternocephalicus muscle in the repair of a partial defect in the trachea of a rabbit (Oryctolagus cuniculus)

Purpose: The current study aimed at evaluating the repair of a partial defect of the trachea with a muscle flap, an advanced technique that employs combined suture patterns. Methods: Sixteen healthy male New Zealand white rabbits were used as an experimental model. A partial defect in the trachea within the ventral region of the fourth to eighth tracheal ring was created. Subsequently, repair was initiated with a flap of the sternocephalicus muscle. The animals were divided into four groups for postoperative evaluation using clinical, tracheoscopic, and histopathological analyses. Each group was separated according to the time of euthanasia, programmed at interval of seven (G7), 15 (G15), 30 (G30), and 60 days (G60). Results: One animal from the G60 group died, whereas the other animals had good surgical recovery without serious changes in the breathing pattern. The major clinical signs observed were stridor and coughing. Tracheoscopy revealed secretions in the tracheal lumen, exuberant granulation, and stenosis. Histopathological analysis showed growth of the ciliary respiratory epithelium at the flap site 30 days after implantation. Conclusions: Partial repair showed satisfactory results owing to the anatomical location of the muscle, adequate vascular support, and structural and physiological maintenance without serious changes in the respiratory system.

Place of plasma argon coagulation in the treatment of vascular abnormalities of the digestive tract in adults

The aim of our study is to evaluate the value of Argon Plasma Coagulation in the treatment of gastrointestinal vascular abnormalities. Patients and methods: This is a descriptive and analytical retrospective study, from January 2009 to September 2020. 198 patients who have benefited from treatment with Argon Plasma Coagulation for vascular anomalies of the digestive tract divided into 2 groups: -Group A: Patients with radial rectitis lesions (n = 107). -Group B: Patients with lesions of digestive angiodysplasia (n = 91). Results: The mean age of our patients was 64.95 ± 9.88 years [43 - 83] in group A, while in group B the mean age was 65.19 ± 14.29 years [40 - 91] with a clear male predominance in 72.5%. The majority of patients in group A were followed for prostate cancer in 33,8%, and 26.3% of patients in group B had chronic renal failure, followed by stomach cancer in 15.8%, and esophageal cancer in 10.5%. Clinical symptomatology was dominated by rectories in 40.2% in group A versus 46.8% in group B. Rectal involvement was dominated in group A in 98.1%, whereas in group B the lesions were mainly located in the stomach in 60.5%. The endoscopic evolution was favorable in all our patients with a clear improvement of rectal lesions and digestive angiodysplasia lesions. The total complication rate in our series was nil. Conclusion: Plasma Argon coagulation is a very effective method in the endoscopic treatment of digestive haemorrhages with good tolerability and a low complication rate. (AU)

Prognostic roles and survival benefits of endoscopic resection versus surgical resection in the management of malignant colon polyps

Background: Due to few sufficient data regarding the comparison between endoscopic and surgical resection of malignant colorectal polyps regarding outcomes and survival benefits, there are no clear guidelines of management strategies of malignant colorectal polyps. The aims of the present study were to compare endoscopic resection alone and surgical resection in patients with malignant polyps in the colon (T1N0M0) readings advantages, disadvantages, recurrence risks, survival benefits, and long-term prognosis to detect how management strategy affects outcome. Patients and methods: we included 350 patients. All included patients were divided into 2 groups; the first group included 100 patients who underwent only endoscopic polypectomy and the second group included 250 patients who underwent endoscopic polypectomy followed by definitive surgical resection after histopathological diagnosis. We followed all patients for about 5 years, ranging from 18 to 55 months. The primarily evaluated parameters are surgical consequences and patients' morbidity. The secondary evaluated parameters are recurrence risks, recurrence free survival, and overall survival rates. Results: The age of patients who underwent polypectomy is usually younger than the surgical group, males have more liability to polypectomy in comparison with females. Patients with tumors in the left colon have more liability to polypectomy in comparison with the right colon (p< 0.0001). Tumor factors associated with more liability to surgical resection are presence of lymphovascular invasion, high grade, and poor tumor differentiation (p< 0.0001). The management strategy was the most significant predictor of overall and recurrence free survival rates in patients with malignant colon polyps (p< 0.001). Conclusions: We found that survival benefits and lower incidence of recurrence are detected in the surgical resection group more than in the polypectomy group. (AU)

Abordaje endoscópico extendido del seno frontal: Experiencia en Hospital Clínico Universidad de Chile / Extended endoscopic approach of the frontal sinus: Experience at Hospital Clínico Universidad de Chile

Introducción: El seno frontal es una estructura compleja y desafiante en términos quirúrgicos, siendo descritas numerosas técnicas para su abordaje. Dentro de ellas se destaca el abordaje endoscópico extendido de seno frontal: Draf IIB y Draf III, como una importante alternativa para resolución de patología refractaria de seno frontal. Objetivo: Describir las características de pacientes sometidos a abordaje endoscópico extendido de seno frontal en Hospital Clínico Universidad de Chile (HCUCH). Material y Método: Estudio retrospectivo, descriptivo. Se incluyeron a pacientes sometidos a abordaje endoscópico extendido de seno frontal entre los años 2013 y 2021. Se analizaron variables clínicas, intraoperatorias y de seguimiento. Resultados: Se registraron 118 pacientes, de los cuales 64 cumplieron criterios de inclusión al estudio, con una edad promedio de 48 años. La patología más frecuente fue la rinosinusitis crónica poliposa (42%) seguido del mucocele (20%). Del total de pacientes, el 68% fue sometido a cirugía Draf IIB y el resto a Draf III. Todos los pacientes fueron estudiados con endoscopía e imágenes, y seguidos con parámetros clínicos y endoscópicos. El porcentaje de estenosis postoperatoria se estimó en 10%. Conclusión: El abordaje endoscópico nasal extendido figura como una alternativa útil para manejo de patología de seno frontal refractario a tratamiento. En nuestra experiencia las indicaciones, tipos de cirugía y tasa de complicaciones son concordantes con la literatura internacional.

Introduction: The frontal sinus is a complex and challenging structure in surgical terms, numerous techniques have been described for its approach, among them the extended endoscopic approach: Draf IIB and Draf III, figures as an important alternative for the resolution of refractory pathology of frontal sinus. Aim: To describe the characteristics of patients who underwent an extended endoscopic approach to the frontal sinus at the Hospital Clínico Universidad de Chile (HCUCH). Material and Method: A retrospective, descriptive study included patients who underwent an extended endoscopic approach to the frontal sinus between 2013 and 2021. Clinical, intraoperative, and follow-up variables were analyzed. Results: 118 patients were registered, of which 64 met the inclusion criteria for the study, with an average age of 48 years. The most frequent pathology was chronic polypous rhinosinusitis (42%), followed by mucocele (20%). Of the patients, 68% underwent Draf IIB surgery, while the rest received a Draf III type procedure. All patients were studied with endoscopy and images and followed up with clinical and endoscopic parameters. The percentage of post operatory stenosis was 10%. Conclusion: The extended nasal endoscopic approach appears as a valuable alternative for managing frontal sinus pathology refractory to treatment. In our experience, the indications, types of surgery, and rate of complications are consistent with the international literature.

Neurofibromatosis laríngea pediátrica: reporte de localización atípica / Pediatric neurofibromatosis of the larynx: report of atypical location

Los neurofibromas laríngeos (NFL) son tumores benignos poco frecuentes de localización principalmente supraglótica. Se manifiestan con síntomas obstructivos de la vía aérea. El tratamiento es la resección completa del tumor mediante abordaje endoscópico; se reserva la cirugía abierta para tumores de gran extensión. Se presenta el caso de un paciente pediátrico con localización atípica de NFL asociado a neurofibromatosis tipo 1 (NF1). Se realizó resección endoscópica del tumor y la anatomía patológica informó neurofibroma plexiforme. Es importante sospechar de esta patología en todo niño con estridor inspiratorio atípico progresivo. Se sugiere seguimiento a largo plazo por la alta probabilidad de recidiva.

Laryngeal neurofibromas (LNFs) are rare benign tumors mainly located in the supraglottis. LNFs occur with airway obstruction symptoms. The treatment is complete resection via an endoscopic technique; the open approach is reserved for large tumors. Here we describe the case of a pediatric patient with LNF of atypical location associated with neurofibromatosis type 1 (NF-1). The tumor was resected with an endoscopic technique, and the pathological study reported a plexiform neurofibroma. It is important to suspect this condition in any child with atypical, progressive inspiratory stridor. Long-term follow-up is recommended due to the high rate of recurrence

Características clínicas y hallazgos endoscópicos en niños con hipertensión portal atendidos en un hospital pediátrico / Clinical characteristics and endoscopic findings in children with portal hypertension seen in a pediatric hospital

Antecedentes: El término hipertensión portal (HP) se define como el aumento patológico en el gradiente de presión porto-sistémico en cualquier segmento del sistema venoso portal. Objetivo: Determinar las características clínicas y hallazgos endoscópicos de pacientes con HP atendidos en el Hospital María, Especialidades Pediátricas (HMEP). Métodos: Se realizó un estudio observacional, descriptivo y retrospectivo. El universo fueron todos los pacientes de 18 años o menos con diagnóstico de HP que asistieron al servicio de gastroenterología pediátrica del HMEP entre 2015-2022. Fue tomado todo el universo para aná- lisis. Se realizó análisis de datos descriptivo univariado utilizando el programa STATA 15.1. Resultados: Se analizó un total de 38 pacientes, 55.3% (21/38) de edad preescolar. El 57.9% (22/38) fue masculino y el nivel de escolaridad más frecuente fue primaria incompleta en 55.3%. La procedencia en 79% (30/38) de la zona centro y oriente del país. El Sangrado Digestivo Alto (SDA) se en- contró en 42% de los pacientes (16/38) y la etiología pre-hepática fue la más frecuente en 65.8 % (25). Discusión: se encontró que el inicio de la enfermedad fue en pre-escolares con predominio del sexo masculino; las causas pre-hepáticas fueron la etiología más frecuente de SDA coincidiendo con lo publicado por otros autores. El SDA fue el síntoma inicial predominante, evidenciado en hallazgos endoscópicos como várices esofágicas y gástricas. Conclusión: La HP es poco frecuente en edad pediátrica tiene consecuencias severas en la calidad de vida y sobrevida del paciente...(AU)

Divertículo de Zenker / Zenker's Diverticulum

Introducción: Los divertículos de Zenker son los más frecuentes del esófago. El tratamiento quirúrgico más utilizado es la diverticulectomía con miotomía cricofaríngea abierta. Objetivo: Describir un paciente con diagnóstico de divertículo de Zenker cuya presentación fue la disfagia e infecciones respiratorias recurrentes. Presentación del caso: Describimos el caso de una paciente de 73 años con disfagia alta e infecciones respiratorias recurrentes, con el diagnóstico de divertículo de Zenker, a quien se le realiza diverticulectomía más miotomía. Conclusiones: El divertículo de Zenker o divertículo yuxtaesfinteriano faringoesofágico es una entidad de baja prevalencia que se presenta en pacientes entre los 50 y 70 años, predominantemente en los de sexo masculino. La radiografía contrastada del tracto digestivo superior y endoscopia determinan el diagnóstico en su mayoría y la diverticulectomía más cricomiotomía es la técnica más empleada(AU)

Introduction: Zenker's diverticula are the most frequent diverticula of the esophagus. The most commonly used surgical treatment is diverticulectomy with open cricopharyngeal myotomy. Objective: To describe a patient with a diagnosis of Zenker's diverticulum and whose presentation was dysphagia and recurrent respiratory infections. Case presentation: We describe the case of a 73-year-old female patient with high dysphagia and recurrent respiratory infections, with the diagnosis of Zenker's diverticulum, and who underwent diverticulectomy plus myotomy. Conclusions: Zenker's diverticulum or pharyngoesophageal juxtasphincteric diverticulum is a low-prevalence condition that occurs in patients between 50 and 70 years of age, predominantly in males. Contrast radiography of the upper digestive tract and endoscopy determine the diagnosis in the majority of cases, while diverticulectomy plus cricomyotomy is the most commonly used technique(AU)

Endoscopic Cubital Tunnel Release in Leprosy Neuritis of the Ulnar Nerve / Liberação endoscópica do túnel cubital na neurite hansênica do nervo ulnar

Abstract Objectives To better characterize the role of endoscopic cubital tunnel release in leprosy neuritis and determine whether there is an improvement in pain, sensitivity, and strength with the use of this minimally invasive technique. Methods A total of 44 endoscopic procedures for ulnar nerve decompression at the elbow were performed in patients who were previously diagnosed with leprosy neuritis. The inclusion criteria were surgical indication for ulnar nerve release and clinical treatment failure for 4 weeks in patients with cubital tunnel syndrome who had their ulnar nerve function, whether motor or sensitive, deteriorated progressively despite the treatment with prednisone 1 mg/kg/day and physiotherapy. For endoscopic release, the CTS Relief Kit (Linvatec. Largo, FL, USA) and a standard 4mm 30° arthroscope were used. Results The study included 39 patients, 29 (74.4%) males and 10 (25.6%) females. The age of the patients ranged from 12 to 64 years (33 ± 14.97). Five patients underwent bilateral release. The release demonstrated a statistically significant improvement in pain (p 0.002), in sensitivity (p< 0.001), and in strength (p< 0.001). The best results were obtained when ulnar release was performed less than 6 months after surgery indication. None of the procedures were converted from endoscopic to open. No major complications (infection, vascular injury, and nervous injury) were reported. One patient had ulnar nerve subluxation. Conclusion The endoscopic release of the ulnar nerve at the elbow in leprosy neuritis entails true and safe benefits for the patient, such as improvement in pain, sensitivity and strength.

Resumo Objetivos Os objetivos deste estudo foram caracterizar melhor o papel da liberação endoscópica do túnel cubital na neurite hansênica e determinar se há melhora da dor, sensibilidade e força com esta técnica minimamente invasiva. Métodos Um total de 44 procedimentos endoscópicos para descompressão do nervo ulnar no cotovelo foram realizados em pacientes previamente diagnosticados com neurite por hanseníase. Os critérios de inclusão foram indicação cirúrgica para liberação do nervo ulnar e insucesso do tratamento clínico por 4 semanas em pacientes com síndrome do túnel cubital que sofreram deterioração progressiva da função motora ou sensitiva do nervo ulnar apesar do tratamento de 1 mg/kg/dia de prednisona e fisioterapia. A liberação endoscópica foi realizada com CTS Relief Kit (Linvatec. Largo, FL, EUA) e um artroscópio padrão de 4 mm e 30°. Resultados O estudo incluiu 39 pacientes, sendo 29 (74,4%) homens e 10 (25,6%) mulheres. A idade dos pacientes variou de 12 a 64 anos (33 ± 14,97). Cinco pacientes foram submetidos à liberação bilateral. A liberação provocou melhora estatisticamente significativa de dor (p= 0,002), sensibilidade (p <0,001) e força (p <0,001). Os melhores resultados foram obtidos quando a liberação ulnar foi realizada em menos de 6 meses após a indicação da cirurgia. Nenhum procedimento foi convertido de endoscópico para aberto. Não foram relatadas complicações maiores (infecção, lesão vascular e lesão nervosa). Um paciente apresentou subluxação do nervo ulnar. Conclusão A liberação endoscópica do nervo ulnar no cotovelo na neurite hansênica traz benefícios verdadeiros e seguros para o paciente, como melhora da dor, sensibilidade e força.

Remoção endoscópica de corpo estranho ventricular em gallus gallus domesticus da raça brahma: relato de caso / Endoscopic removal of a ventricular foreign body in a brahma gallus domesticus: case report / Extracción endoscópica de un cuerpo extraño ventricular en un brahma gallus domesticus: informe de un caso

Relatos de ingestão de corpos estranhos dos mais diferentes materiais são comuns em aves, especialmente nas mais jovens. Os corpos estranhos podem causar intoxicação (dependendo da composição do material) ou mesmo perfuração do canal alimentar ou obstrução gastrintestinal. Quando há suspeita de ingestão de corpos estranhos, exames de imagem como a radiologia, ultrassonografia e endoscopia são ferramentas valiosas para o diagnóstico. Objetivou-se relatar um caso de uma ave da espécie Gallus gallus domesticus, raça Brahma, sete meses de idade, macho, pesando 4,3 Kg com quadro de sensibilidade na cavidade corporal e histórico de regurgitação, hiporexia e prostração há cinco dias. As radiografias simples indicaram a presença de corpo estranho radiopaco (parafuso) alojado na região do ventrículo (moela). Após tratamento clínico com lavagens gástricas por cinco dias sem êxito, optou-se por realizar uma endoscopia digestiva alta sob anestesia geral com quetamina e isoflurano. O corpo estranho foi satisfatoriamente removido com pinça de alça de polipectomia e a ave apresentou rápida melhora clínica sem complicações. A endoscopia mostrou-se um procedimento pouco invasivo e eficaz para a resolução do presente caso. Os clínicos veterinários de aves devem considerar a possibilidade de usar a endoscopia como ferramenta para diagnóstico e resolução de corpos estranhos no canal alimentar das aves.(AU)

Reports of ingestion of foreign bodies from most different materials are common in birds, especially younger ones. Foreign bodies can cause intoxication (depending on the composition of the material) or even perforation of the alimentary canal and gastrointestinal obstruction. When foreign body ingestion is suspected, imaging tests such as radiology, ultrasound, and endoscopy are valuable diagnostic tools. The objective of this paper was to report a case of an avian of the species Gallus gallus domesticus, Brahma breed, seven months old, male, weighing 4.3 kg, with sensitivity in the body cavity, and a history of regurgitation, hyporexia, and prostration for five days. Plain radiographs indicated the presence of a radiopaque foreign body (screw) lodged in the ventricle region (gizzard). After clinical treatment with gastric lavages for five days without success, it was decided to perform an upper digestive endoscopy under general anesthesia with ketamine and isoflurane. The foreign body was satisfactorily removed with polypectomy loop forceps, and the bird showed rapid clinical improvement without complications. Endoscopy proved to be a minimally invasive and effective procedure for resolving the present case. Avian veterinary practitioners may consider using endoscopy to diagnose and resolve foreign bodies in the alimentary canal of birds.(AU)

Los informes de ingestión de cuerpos extraños de los más diferentes materiales son comunes en las aves, especialmente en las más jóvenes. Los cuerpos extraños pueden causar intoxicación (dependiendo de la composición del material) o incluso perforación del tubo digestivo u obstrucción gastrointestinal. Cuando se sospecha la ingestión de un cuerpo extraño, las pruebas de imagen como la radiología, la ecografía y la endoscopia son valiosas herramientas diagnósticas. El objetivo fue reportar un caso de un ave de la especie Gallus gallus domesticus, raza Brahma, de siete meses de edad, macho, con un peso de 4,3 kg, con sensibilidad en la cavidad corporal y antecedentes de regurgitación, hiporexia y postración de cinco días de evolución. Las radiografías simples indicaron la presencia de un cuerpo extraño radiopaco (tornillo) alojado en la región del ventrículo (molleja). Tras tratamiento clínico con lavados gástricos durante cinco días sin éxito, se decide realizar endoscopia digestiva alta bajo anestesia general con ketamina e isoflurano. El cuerpo extraño se extrajo satisfactoriamente con pinzas de asa de polipectomía y el ave mostró una rápida mejoría clínica sin complicaciones. La endoscopia demostró ser un procedimiento mínimamente invasivo y efectivo para la resolución del presente caso. Los veterinarios aviares deberían considerar la posibilidad de utilizar la endoscopia como herramienta para el diagnóstico y resolución de cuerpos extraños en el tubo digestivo de las aves.(AU)

Seguridad de los portales para la reparación endoscópica del ligamento calcaneonavicular: estudio cadavérico / Endoscopic Spring ligament repair. Anatomic evaluation of portal safety

Introducción: La lesión del ligamento calcaneonavicular ha sido descrita como una de las causas de la deformidad en el pie plano del adulto. El objetivo de este artículo es describir portales modificados para el diagnóstico y la reparación endoscópica de las lesiones del fascículo superomedial del ligamento calcaneonavicular y evaluar la seguridad de los portales utilizados. Materiales y Métodos:Se llevó a cabo un estudio cadavérico con seis preparados reproduciendo una lesión del fascículo superomedial del ligamento calcaneonavicular con una punta de corte de radiofrecuencia y la posterior reparación endoscópica. Se crearon dos portales modificados para el abordaje. Luego se procedió a la disección anatómica para evaluar la seguridad de los portales en relación con las estructuras anatómicas. El primer portal se realiza inmediatamente proximal a una línea trazada desde la punta del maléolo medial dirigida al centro del talón, el segundo portal se emplaza 0,5 cm proximal a la inserción del tendón tibial posterior en el escafoides por transiluminación. Si es necesario, se coloca un portal accesorio inmediatamente dorsal al tendón tibial posterior a mitad de camino entre los dos portales antes descritos. Resultados:En todos los casos, fue posible la reparación del ligamento con el procedimiento endoscópico. En la disección anatómica de los portales, se observó una distancia promedio a las estructuras vasculonerviosas de 11,83 mm del portal proximal y de 9,66 mm del portal distal. Conclusión: Los portales modificados son seguros y permiten la visualización directa del haz superomedial del ligamento calcaneonavicular y su reparación endoscópica. Nivel de Evidencia: IV

Introduction: Calcaneonavicular ligament injury has been described as a cause of adult flat foot deformity. The objective of this study is to describe modified portals for the diagnosis and treatment of injuries to the superomedial bundle of the calcaneonavicular ligament and to evaluate the safety of the portals used. Materials and Methods: We performed a cadaveric specimen study on 6 feet, where we reproduced a lesion of the superomedial bundle of the calcaneonavicular ligament with a radiofrequency ablation device and repaired it endoscopically. Two modified portals were created for the approach and an anatomical dissection was performed to assess the safety of the portals in relation to the anatomical structures. The first portal was placed immediately proximal to a line drawn from the tip of the medial malleolus toward the center of the heel; the second portal was placed 0.5 cm proximal to the posterior tibial tendon insertion into the navicular bone, guided by transillumination. If needed, an accessory portal was placed halfway between the two previously described portals immediately dorsal to the posterior tibial tendon. Results:In all cases, ligament repair was achieved with the endoscopic procedure. In the anatomical dissection of the portals, we observed an average distance of 11.83 mm from the proximal portal and 9.66 mm from the distal portal to neurovascular structures. Conclusion:Modified portals are safe and allow direct visualization of the superomedial bundle of the calcaneonavicular ligament to perform endoscopic repair. Level of Evidence: IV

Tratamiento endoscópico de la espondilodiscitis lumbar. Reporte de un caso y revisión bibliográfica / Endoscopic treatment of lumbar spondylodiscitis. Case report and literature review

Se describe el caso de un hombre de 62 años de edad, con múltiples comorbilidades que concurre a la consulta por dolor lumbar severo compatible con espondilodiscitis de T12-L1-L2. Se realizó una endoscopia con abordaje posterolateral izquierdo con técnica adentro-adentro para fines diagnóstico y terapéutico. Se aisló un germen y se administró un tratamiento antibiótico específico. Dada la buena evolución clínica del paciente, fue dado de alta a los 7 días de la cirugía, con buen manejo del dolor y antibióticos intravenosos en el domicilio. Se presenta una breve revisión bibliográfica. Nivel de Evidencia: IV

We describe the case of a 62-year-old male patient with multiple comorbidities who attended the outpatient clinic due to severe low back pain compatible with T12-L1-L2 spondylodiscitis. Endoscopy was performed with a left posterolateral approach and an all-inside technique for diagnostic and therapeutic purposes. A germ was isolated and treated with specific antibiotics. Due to the good clinical evolution, the patient was discharged 7 days after surgery with good pain management and home intravenous antibiotic therapy. A brief literature review is presented. Level of Evidence: IV

Awake nasotracheal intubation with a 300-mm working length fiberscope: a prospective observational feasibility trial

Abstract Background: Awake fiberoptic tracheal intubation is an established method of securing difficult airways, but there are some reservations about its use because many practitioners find it technically complicated, time-consuming, and unpleasant for patients. Our main goal was to test the safety and efficacy of a 300-mm working length fiberscope (video rhino-laryngoscope) when used for awake nasotracheal intubation in difficult airway cases. Methods: This was a prospective, single-center study involving adult patients, having an ASA physical status between I and IV, with laryngopharyngeal pathology causing distorted airway anatomy. Awake nasotracheal intubation, using topical anesthesia and light sedation, was performed using a 300 mm long and 2.9 mm diameter fiberscope equipped with a lubricated reinforced endotracheal tube. The primary outcomes were the success and duration of the procedure. Patients' periprocedural satisfaction and other incidents were recorded. Results: We successfully intubated all 25 patients included in this study. The mean ± SD duration of the procedure, starting from the passage of the intubating tube through one of the nostrils until the endotracheal intubation, was 76 ± 36 seconds. Most of the patients showed no discomfort during the procedure with statistical significance between the No reaction Group with the Slight grimacing Group (95%CI 0.13, 0.53, p = 0.047) and the Heavy grimacing Group (95%CI 0.05, 0.83, p = 0.003). The mean ±SD satisfaction score 24 hours post-intervention was 1.8 ± 0.86 - mild discomfort. No significant incidents occurred. Conclusions: Our study showed that a 300-mm working length flexible endoscope is fast, safe, and well-tolerated for nasotracheal awake intubation under challenging airways.

Enfermedades raras en la infancia. Visión gastroenterológica / Rare Diseases in Childhood. Gastroenterological View

Introducción: Las enfermedades raras conforman las afecciones de baja prevalencia que asociadas a los medicamentos huérfanos representan un problema sanitario y social mundial. Objetivo: Revisar los aspectos más sobresalientes relacionados con las enfermedades raras, con una visión gastroenterológica, y su repercusión en la infancia. Métodos: Se realizaron búsquedas no estructuradas de publicaciones en español e inglés en PubMed, Google Scholar, Scimago, SciELO, desde enero 2010 hasta agosto 2021. Se usaron los términos: enfermedades raras, conceptualización, prevalencia, epidemiología, medicamentos huérfanos y ética. Análisis y síntesis de la información: Se revisaron las enfermedades raras en la infancia, criterios conceptuales, epidemiología global, enfermedades más reconocidas con énfasis en gastroenterología. Se destacó la prevalencia, vínculo genético, importancia social, dilema diagnóstico y categorías; repercusión de los tratamientos con medicamentos huérfanos, sus costos y problemas éticos. Se resaltó la incidencia de enfermedades digestivas y el valor de la endoscopia y la biopsia en el diagnóstico. Conclusiones: Se documentaron las enfermedades raras en la infancia, y se analizaron como problema mundial, sanitario y social. El desarrollo de la técnica y de la ciencia, resultaron contribuciones decisivas que variaron criterios sobre diferentes afecciones catalogadas como raras(AU)

Introduction: Rare diseases are the conditions of low prevalence associated with orphan drugs and they represent a global health and social problem. Objective: To review the most outstanding aspects related to rare diseases, with a gastroenterological view, and their impact on childhood. Methods: Unstructured searches for publications in Spanish and English in PubMed, Google Scholar, Scimago, SciELO were conducted, from January 2010 to August 2021. The terms rare diseases, conceptualization, prevalence, epidemiology, orphan drugs and ethics were used. Analysis and synthesis of information: Rare diseases in childhood, conceptual criteria, global epidemiology, and the most well-known diseases with emphasis on gastroenterology were reviewed. Prevalence, genetic link, social importance, diagnostic dilemma and categories, also the impact of orphan drug treatments, their costs and ethical problems were highlighted. The incidence of digestive diseases and the value of endoscopy and biopsy in diagnosis were highlighted. Conclusions: Rare diseases in childhood were documented and analyzed as a global health and social problem. The development of technique and science were decisive contributions that varied criteria on different conditions classified as rare(AU)

Devenir de la pose de la sonde double J pour obstruction du haut appareil urinaire Etude documentaire d'une série des cas du Centre National Hospitalo-Universitaire Hubert Koutoukou Mage à Cotonou, Benin / Outcome of the installation of the double J probe for upper urinary tract obstruction: A case series from the Hubert Koutoukou Mage National University Hospital, Cotonou, Benin

Contexte et objectifs. La sonde double J est très utilisée de nos jours dans le drainage des urines du haut appareil. L'objectif de la présente étude était de décrire le devenir de la pose de la sonde double J. Méthodes. Il s'est agi d'une étude documentaire d'une série des cas ayant bénéficié d'un drainage urinaire du haut appareil par une sonde double J au Centre National Hospitalo-Universitaire Hubert Koutoukou Maga de Cotonou, Bénin ; entre les 1er avril 2018 et 31 mars 2021. Résultats. Les dossiers de cent trois patients (âge moyen 48,4 ans, sexe masculin, 58,3 %) ont été colligés. La pose de la sonde double J représentait 84,74 %. La pose de la sonde double J était unilatérale dans 76,7 % des cas avec une prédominance à droite (56,0 %). L'abord par voie endoscopique pour la pose de la sonde double J était la plus pratiquée (89,3 %). La pose de la sonde double J a été effectuée sans guidage fluoroscopique (à l'aveugle) dans 73,7 % et la durée moyenne du port de cette sonde était 118,37 jours. La fonction rénale était perturbée avec un débit de filtration glomérulaire < 60 ml/minute/1,75 m2 chez 33,0 % des patients. Les étiologies à la base d'une obstruction étaient dominées par la pathologie lithiasique (63,1 %). Le taux de réussite de la sonde double J était de 77,6 %. Les échecs de la sonde double J étaient dus aux pathologies tumorales dans 15,53 %. La durée moyenne d'hospitalisation après la pose de la sonde double J par voie endoscopique était de 7,72 jours. Conclusion. Le syndrome obstructif surtout d'origine lithiasique reste la plus importante indication de l'usage de la sonde double J. Sa réalisation sans guidage fluoroscopique (à l'aveugle) est possible dans le milieu ne disposant pas d'amplificateur de brillance.

Gasless submental approach endoscopic removal of thyroglossal cyst / 中华耳鼻咽喉头颈外科杂志

Objective: To explore the safety and feasibility of gasless submental approach endoscopic removal of thyroglossal cyst. Methods: This work prospectively included the clinical data of 13 patients who underwent the gasless submental approach endoscopic removal of thyroglossal cyst at the Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University from August 2021 to February 2022. The operative time, bleeding volumes, postoperative complications, subjective pain levels, satisfaction with incisional scars, neck and facial deformities, and recurrences were prospectively evaluated by visual analogue scale(VAS) score. Results: All of 13 patients were successfully treated using this new technique. The patients had a median age of 38 years, ranging from 24 to 59 years, comprising of 3 males and 10 females. The length of the submental incision was about 3 cm and the median of operation time was 135 minutes. Postoperative complications were minimal. The median volume of blood loss was 10 ml. Surgical site swelling existed in 1 case and dysphagia for more than 1 week occurred in 2 cases. Patients were discharged from the hospital with a median of 3 days after surgery. On a VAS of 0-10 scores, the pain had a median of 2 on the first day after surgery, and the satisfaction with incision scars and neck and facial deformities showed a median of 8 at 6 months after surgery. There were no recurrences during the follow-up period of 9-15 months. Conclusion: Gasless submental approach endoscopic removal of thyroglossal cyst may be a reliable new surgical method that is safe and has cosmetic advantages.

Endoscopic transoral approach nasopharyngectomy for petroclival and jugular foramen nasopharyngeal carcinoma / 中华耳鼻咽喉头颈外科杂志

Objective: To describe a technique of endoscopic transoral approach nasopharyngectomy for petroclival and jugular foramen nasopharyngeal carcinoma, based on anatomic studies and surgeries. Methods: Three dry human skulls and five fresh human cadaver heads were used for anatomic study of a endoscopic transoral approach to expose petroclival and jugular foramen. The anatomical landmarks and the extent of exposure were recorded. Six clinical cases who were treated in Eye & ENT Hospital, Fudan University from June 2020 to April 2022 were used to illustrate the technique and feasibility of this approach and to assess its indications and advantages, including 3 males and 3 females, aged 42 to 69 years old. Descriptive analysis was used in this research. Results: On the basis of the preservation of the internal pterygoid muscle and the external pterygoid muscle, this approach could fully expose the parapharyngeal, petrosal and paraclival segment internal carotid arteries, and safely deal with the lesions of jugular foramen and petroclival region. The 6 patients in our study tolerated the procedure well. Postoperative enhanced MRI showed complete resection of the tumor and no postoperative masticatory dysfunction. Conclusion: Endoscopic transoral approach is a safe, minimally invasive and effective surgical treatment for petroclival and jugular foramen recurrent nasopharyngeal carcinoma.

Risk factors for residual cancer or lymph node metastasis after endoscopic noncurable resection of early colorectal cancer / 中华肿瘤杂志

Objective: Risk factors related to residual cancer or lymph node metastasis after endoscopic non-curative resection of early colorectal cancer were analyzed to predict the risk of residual cancer or lymph node metastasis, optimize the indications of radical surgical surgery, and avoid excessive additional surgical operations. Methods: Clinical data of 81 patients who received endoscopic treatment for early colorectal cancer in the Department of Endoscopy, Cancer Hospital, Chinese Academy of Medical Sciences from 2009 to 2019 and received additional radical surgical surgery after endoscopic resection with pathological indication of non-curative resection were collected to analyze the relationship between various factors and the risk of residual cancer or lymph node metastasis after endoscopic resection. Results: Of the 81 patients, 17 (21.0%) were positive for residual cancer or lymph node metastasis, while 64 (79.0%) were negative. Among 17 patients with residual cancer or positive lymph node metastasis, 3 patients had only residual cancer (2 patients with positive vertical cutting edge). 11 patients had only lymph node metastasis, and 3 patients had both residual cancer and lymph node metastasis. Lesion location, poorly differentiated cancer, depth of submucosal invasion ≥2 000 μm, venous invasion were associated with residual cancer or lymph node metastasis after endoscopic (P<0.05). Logistic multivariate regression analysis showed that poorly differentiated cancer (OR=5.513, 95% CI: 1.423, 21.352, P=0.013) was an independent risk factor for residual cancer or lymph node metastasis after endoscopic non-curative resection of early colorectal cancer. Conclusions: For early colorectal cancer after endoscopic non-curable resection, residual cancer or lymph node metastasis is associated with poorly differentiated cancer, depth of submucosal invasion ≥2 000 μm, venous invasion and the lesions are located in the descending colon, transverse colon, ascending colon and cecum with the postoperative mucosal pathology result. For early colorectal cancer, poorly differentiated cancer is an independent risk factor for residual cancer or lymph node metastasis after endoscopic non-curative resection, which is suggested that radical surgery should be added after endoscopic treatment.

Value of Improved Mayo Endoscopic Score for evaluating treatment efficacy for active ulcerative colitis / 南方医科大学学报

OBJECTIVE@#To assess the value of Improved Mayo Endoscopic Score (IMES) for evaluation of treatment efficacy for active ulcerative colitis (UC).@*METHODS@#We retrospectively analyzed the clinical and endoscopic data of 103 patients diagnosed with active UC in Beijing Tsinghua Changgung Hospital from January, 2015 to December, 2020. The severity of endoscopic lesions was determined by Mayo Endoscopic Score and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and the area of the endoscopic lesions was evaluated based on the Montreal classification system. The IMES was established by combining the MES with the Montreal classification.@*RESULTS@#Univariate analysis suggested that young patients (<40 years old), patients with extensive disease type (E3), patients with high endoscopic scores (MES=3, UCEIS>4, and IMES>4), and patients receiving advanced drug therapy (with systemic hormones, immunosuppressants, immunomodulators, and biological agents, etc.) had lower clinical and endoscopic remission rates. COX survival analysis showed that IMES≤4 was an independent risk factor for clinical and endoscopic remission. ROC curve indicated that the predictive value of IMSE≤4 for clinical and endoscopic remission (AUC=0.7793 and 0.7095, respectively; P<0.01) was better than that of Montreal (AUC=0.7357 and 0.6847, respectively; P<0.01), MES=2 (AUC=0.6671 and 0.5929, respectively; P<0.01), and UCEIS≤4 (AUC=0.6823 and 0.6459, respectively; P<0.01); IMES=5 had a better predictive value for patients with active UC undergoing colectomy tham E3 and MES=3.@*CONCLUSION@#IMES has good value in evaluating treatment efficacy for active UC.